Beth Bradfield (Patty Duke) is a housewife with what appears to be a stable life in an American village. One day, her 24-year-old daughter Lori (Tracey Gold), who is married to Jesse Molina (Maurice Benard) and recently gave birth to his daughter Molly (Laura and Megan Jaime), unexpectedly collapses and is hospitalized. After several tests, she is diagnosed with leukemia. Her doctor (Erick Avari) reveals to Beth that Lori is in urgent need of a donor, though her rare blood type makes finding one a difficult task.