Naive slackers Sam and Alex are hired by a frightening cartel boss to deliver a cardboard box from LA to Vegas for the tidy sum of $10k. Instructed not to look in the box, the duo can’t contain their curiosity, and as soon as they drive off the property, they pull over and have a peek. Much to their surprise and confusion, the box contains six toads. Unbeknownst to them, they’re Sonoran Desert Toads, aka acid toads, which, when licked, get the most seasoned drug enthusiasts high out of their minds. On the road, the soaring desert temperatures cause the toads to develop heatstroke, triggering the duo to jump into rescue mode and give them CPR—and a psychedelic odyssey unfolds.